FARNESYLTRANSFERASE INHIBITOR LONAFARNIB SUPPRESSES RESPIRATORY SYNCYTIAL VIRUS INFECTION BY BLOCKING CONFORMATIONAL CHANGE OF FUSION GLYCOPROTEIN

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Abstract Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly.There are currently no approved RSV-specific therapeutic small molecules available.Using high-throughput antiviral screening, we identified an oral drug, the prenylation inhibitor lonafarnib, which showed potent inhibition

read more

Wave-to-grid (W2G) control of a wave energy converter

Grid integration of wave energy involves various power train stages from device to grid, such as a power take-off stage, a power conversion stage, and a power conditioning stage.The coupled performance of the complete wave-to-grid system depends heavily on the dynamics of Knife Case each stage and their respective controllers.However, the control o

read more